Effect of dietary α-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mi
نویسندگان
چکیده
The effects of α-lipoic acid (ALA) on the growth, body composition, postmortem AMP-activated protein kinase (AMPK) activation, and 24-h muscle pH were investigated. Thirty male C57BL/6J mice were fed diets containing 0, 0.5, or 1.0% ALA (DM basis). At the end of the 3-wk feeding trial, carcass weights decreased (P < 0.05) 14 and 30% for mice fed 0.5 and 1.0% ALA, respectively, compared with the 0% group, with decreases in BW as the levels of dietary ALA increased. This change in carcass weight occurred because carcass fat content for mice receiving 0.5 and 1.0% ALA was 7.32 and 8.09% lower (P < 0.05), respectively, than for the 0% ALA treatment, and because gonadal fat decreased (P < 0.05) 85% in mice fed 1.0% ALA compared with those fed 0% ALA. Dietary ALA caused a slight increase (P < 0.05) in carcass moisture content, with no (P = 0.07) effect on protein and ash content. Furthermore, ALA supplement decreased (P < 0.05) ADFI (DM basis) from 4.3 g/d for 0% ALA-fed mice to 3.4 g/d for
منابع مشابه
α-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate–activated protein kinase–peroxisome proliferator-activated receptor-γ coactivator-1α signaling in the skeletal muscle of aged mice
Skeletal muscle mitochondrial dysfunction is associated with aging and diabetes, which decreases respiratory capacity and increases reactive oxygen species. Lipoic acid (LA) possesses antioxidative and antidiabetic properties. Metabolic action of LA is mediated by activation of adenosine monophosphate–activated protein kinase (AMPK), a cellular energy sensor that can regulate peroxisome prolife...
متن کاملThe Effect of Eight Weeks Aerobic and Resistance Training on AMP-Activated Protein Kinase (AMPK) Gene Expression in Soleus Muscle and Insulin Resistance of STZ-Induced Diabetic Rat
Background: AMPK regulation is one of biggest target in T2D and metabolic syndrome research. Therefore, the present study is aimed to investigate The effect of 8 weeks aerobic and Resistance training on AMP-activated protein kinase (AMPK) gene expression in soleus muscle and insulin resistance of STZ-induced diabetic rat. Methods: The research method of present study was experimental. For this...
متن کاملAntidiabetic effect of the α-lipoic acid γ-cyclodextrin complex
In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a lifestyle-related disease, is recognized as a serious disease with various complications. Many types of pharmaceutics or specific health foods have been used for the management of diabetes mellitus. At the same time, the relationship between diabetes...
متن کاملCorrigendum notice: Protective Effect of Interval Exercise Training with Different Intensity and Alpha-Lipoic Acid Supplement on Nav1.3 Protein in Soleus Muscle of Diabetic Rats
Corrigendum notice: Protective Effect of Interval Exercise Training with Different Intensity and Alpha-Lipoic Acid Supplement on Nav1.3 Protein in Soleus Muscle of Diabetic Rats Seyedeh Fatemeh Fatemi1, Seyed Abdollah Hashemvarzi1, Amin Farzaneh Hesari1 1Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran. *Corresponding author: Tel: 09111160278, email: ...
متن کاملCritical role for free radicals on sprint exercise-induced CaMKII and AMPKα phosphorylation in human skeletal muscle.
The extremely high energy demand elicited by sprint exercise is satisfied by an increase in O2 consumption combined with a high glycolytic rate, leading to a marked lactate accumulation, increased AMP-to-ATP ratio, and reduced NAD(+)/NADH.H(+) and muscle pH, which are accompanied by marked Thr(172) AMP-activated protein kinase (AMPK)-α phosphorylation during the recovery period by a mechanism n...
متن کامل